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The data of a patient with autosomal dominant optic atrophy (ADOA) and chronic renal insufficiency caused by SSBP1 gene mutation in the Children′s Hospital Affiliated to Zhengzhou University in July 2021 was analyzed retrospectively.Literature was reviewed.The patient was a 10-year-old girl, who visited the hospital due to " growth retardation for the past 3 years and elevated serum creatinine (Scr) for the past 2 years" . On admission, the patient′s height was 130 cm (<10 th percentile of the same sex of healthy age) and her weight was 22 kg (<3 rd precentile of the same sex of healthy age). Lab examination showed that the level of blood urea nitrogen (BUN) was 16.3 mmol/L, Scr was 115.4 μmol/L, and the estimated glomerular filtration rate was 41 mL/(min·1.73 m 2). The patient was complicated with metabolic acidosis and mild anemia.Imaging findings showed small volume of both kidneys, increased background parenchymal enhancement, scattered spot-like hyperechoes and unclear boundary between the cortex and medulla.Additionally, the patient had a history of optic atrophy.Both the father and mother of the patient had no related phenotypes.The genetic test of the patient showed that c. 320G>A (p.R107Q) was a heterozygous missense mutation, which was spontaneous.A total of 5 English papers were retrieved.There were 8 kinds of SSBP1 gene mutations reported, including 7 heterozygous missense mutations [c.320G>A (p.Arg107Gln), c.119G>T (p.Gly40Val), c.331G>C (p.Glu111Gln), c.184A>G (p.Asn62Asp), c.113G>A (p.Arg38Gln), c.422G>A (p.Ser141Asn), c.79G>A (p.Glu27Lys)] and 1 homozygous mutation [c.394A>G (p.Ile132Val)]. Studies have established that almost all patients carrying SSBP1 mutations have manifestations of eye involvement, and that some patients are complicated with progressive deterioration of renal function, sensorineural deafness, growth retardation, and hypothyroidism.It suggests that SSBP1 gene mutation can cause ADOA.For patients with optic atrophy, whether they are complicated with hearing loss and growth retardation, renal morphology and renal function evaluation are recommended.Early genetic examination is helpful for diagnosis and treatment.
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Objective:To investigate the efficacy and safety of plasma exchange(PE) in the treatment of autoimmune hemolytic anemia in children.Methods:The data from 8 hospitals in China during November 2014 to April 2017 were collected, and the clinical characteristics of PE in children with AHA were analyzed retrospectively.Results:A total of 21 children with AHA were included in the study, including 17 cases from PICU and 4 cases from pediatric kidney ward, with 11 boys and 10 girls, and the median age was 3.64(0.25, 11.10)years old, and median hospital stay was 12(4, 45)days.There were 15 cases(71.4%) with infection, 2 cases(9.5%)with autoimmune diseases, 4 cases(19.0%) with unknown.Consciousness disturbance occurred in 4 patients before replacement and recovered to normal after PE.The volume of blood decreased in two cases(9.5%) and completely relieved.There were 20 cases of anemia (95.2%), 15 cases were normal after PE, and 5 cases were improved.Jaundice occurred in 18 cases (85.7%), 12 cases were normal after PE, 6 cases were improved.Hepatosplenomegaly was found in 11 cases, 10 cases were normal after PE, 1 case was improved.After PE, the hemoglobin and red blood cell count increased, while the total bilirubin, indirect bilirubin, urea nitrogen and lactate dehydrogenase decreased, there were significant differences between pre-and post-replacement ( P<0.05). Only 1 case had allergic reaction, which was improved after symptomatic treatment, and PE was continued.After PE, 2 cases (9.5%) had complete remission, 16 cases (76.2%) had partial remission and 3 cases (14.3%) had been discharged. Conclusion:PE therapy can obviously improve the clinical symptoms and laboratory indexes of children with AHA who have failed to respond to conservative treatment.It can be used as a treatment measure for children with severe AHA and has a good safety.
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Objective:To investigate the efficacy and safety of plasma exchange(PE) in the treatment of autoimmune hemolytic anemia in children.Methods:The data from 8 hospitals in China during November 2014 to April 2017 were collected, and the clinical characteristics of PE in children with AHA were analyzed retrospectively.Results:A total of 21 children with AHA were included in the study, including 17 cases from PICU and 4 cases from pediatric kidney ward, with 11 boys and 10 girls, and the median age was 3.64(0.25, 11.10)years old, and median hospital stay was 12(4, 45)days.There were 15 cases(71.4%) with infection, 2 cases(9.5%)with autoimmune diseases, 4 cases(19.0%) with unknown.Consciousness disturbance occurred in 4 patients before replacement and recovered to normal after PE.The volume of blood decreased in two cases(9.5%) and completely relieved.There were 20 cases of anemia (95.2%), 15 cases were normal after PE, and 5 cases were improved.Jaundice occurred in 18 cases (85.7%), 12 cases were normal after PE, 6 cases were improved.Hepatosplenomegaly was found in 11 cases, 10 cases were normal after PE, 1 case was improved.After PE, the hemoglobin and red blood cell count increased, while the total bilirubin, indirect bilirubin, urea nitrogen and lactate dehydrogenase decreased, there were significant differences between pre-and post-replacement ( P<0.05). Only 1 case had allergic reaction, which was improved after symptomatic treatment, and PE was continued.After PE, 2 cases (9.5%) had complete remission, 16 cases (76.2%) had partial remission and 3 cases (14.3%) had been discharged. Conclusion:PE therapy can obviously improve the clinical symptoms and laboratory indexes of children with AHA who have failed to respond to conservative treatment.It can be used as a treatment measure for children with severe AHA and has a good safety.
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Objective To study the demographic and clinical characteristics, correlation of genotype and phenotype and treatment of Blau syndrome to facilitate early diagnosis and timely treatment of Blau syndrome. Methods Seventy-two patients with Blau syndrome from 11 centers from May 2006 to April 2022 were retrospectively analyzed, and their general information, clinical data, laboratory examination and treatment medication were collected. Results The distribution of patients with Blau syndrome was uniform in geographical north and south of China, and there was no obvious gender bias. The mean age of onset was (14.30±12.81) months, and the age of diagnosis was (55.18±36.22) months. 35% of patients with Blau syndrome happened before 1 year old, and all patients developed before 5 years old. 87.50% (63/72) had granulomatous arthritis, 65.28% (47/72) had rash, 36.11% (26/72) had ocular involvement, 27.78% (20/72) had fever, and 15.28% (11/72) had pulmonary involvement. Arthritic manifestations of Blau syndrome were most at risk, followed by rash, ocular involvement, and fever.The first 25 months of the disease, the risk of developing a rash was the greatest. The risk of developing arthritis was the greatest between 25 months and 84 months. The main mutations were p.R334Q and p.R334W, and patients with p.R334Q mutation had relatively high incidence of fever (35.71%[5/14] vs. 14.29%[1/7], P=0.43) and ocular involvement (42.86%[6/14]vs. 28.57%[2/7], P=0.51). There was a relatively high incidence of rash (85.71%[6/7] vs. 64.29%[9/14], P=0.59) in patients with the p.R334W mutation. Forty-five patients(62.50%)were treated with a combina-tion of glucocorticoid and methotrexate. Twenty-two patients were treated with tumor necrosis factor antagonist in addition to glucocorticoid and methotrexate. Conclusions The risk of different clinical manifestations of Blau syndrome from high to low was arthritis, followed by rash, ocular involvement and fever. The main treatment was glucocorticoid combined with methotrexate, to which biological agents could be added.
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Objective To investigate whether silencing UCP2 can sensitize cervical cancer cell line Siha to radiation.Methods Siha cells were transfected with UCP2 siRNA and then irradiated by Xray.The radiosensitivity of Siha cells was verified by colony formation,CCK-8,apoptosis and immunofluorescence assays.The mitochondrial membrane potential and the production of reactive oxygen species (ROS) were detected to further explore the related mechanism.Results RT-PCR and Western blot assays showed that the expression of UCP2 in Siha cells was increased after irradiation and the UCP2 siRNA successfully silenced the expression of UCP in cells.According to the survival curves,the D0,Dq,N and SF2 were 1.54,1.31,2.31 Gy and 0.52 for siUCP2 group,2.50,3.64,4.30 Gy and 0.83 for blank control group,and 3.34,2.16,1.91 Gy and 0.69,for siNC group,respectively.The radiosensitivity enhancement ratio of silent group was 0.62 and 0.46,compared with blank control group and negative control group,respectively.The proliferative activity of cells in the silent group was lower than that in the control group (t =13.2,P＜0.05).Apoptosis levels in the silent group were significantly higher than those in the control group after irradiation (t=3.14,P＜0.05).At 4 h after irradiation,the ROS production in the silent group was significantly higher than that in the control group (t=19.10,P＜0.05).At 24 h after irradiation,the mitochondrial membrane potential of Siha cells in the silent group was significantly lower than that in the control group (t =4.18,P ＜ 0.05) Conclusions The radiosensitivity of Siha cells is enhanced after UCP2 silencing,and thus UCP2 may applicable as a new target for radiosensitization of cervical cancer cells.
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Objective@#To investigate whether silencing UCP2 can sensitize cervical cancer cell line Siha to radiation.@*Methods@#Siha cells were transfected with UCP2 siRNA and then irradiated by X-ray. The radiosensitivity of Siha cells was verified by colony formation, CCK-8, apoptosis and immunofluorescence assays. The mitochondrial membrane potential and the production of reactive oxygen species (ROS) were detected to further explore the related mechanism.@*Results@#RT-PCR and Western blot assays showed that the expression of UCP2 in Siha cells was increased after irradiation and the UCP2 siRNA successfully silenced the expression of UCP in cells. According to the survival curves, the D0, Dq, N and SF2 were 1.54, 1.31, 2.31 Gy and 0.52 for siUCP2 group, 2.50, 3.64, 4.30 Gy and 0.83 for blank control group, and 3.34, 2.16, 1.91 Gy and 0.69, for siNC group, respectively. The radiosensitivity enhancement ratio of silent group was 0.62 and 0.46, compared with blank control group and negative control group, respectively. The proliferative activity of cells in the silent group was lower than that in the control group (t=13.2, P<0.05). Apoptosis levels in the silent group were significantly higher than those in the control group after irradiation(t=3.14, P<0.05). At 4 h after irradiation, the ROS production in the silent group was significantly higher than that in the control group (t=19.10, P<0.05). At 24 h after irradiation, the mitochondrial membrane potential of Siha cells in the silent group was significantly lower than that in the control group (t=4.18, P<0.05).@*Conclusions@#The radiosensitivity of Siha cells is enhanced after UCP2 silencing, and thus UCP2 may applicable as a new target for radiosensitization of cervical cancer cells.
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Objective@#To explore the clinical characteristics of glucocorticoid induced eye damage in children with primary nephrotic syndrome.@*Methods@#The clinical data of steroid-induced high intraocular pressure or cataract in 49 children who were from Zhengzhou Children′s Hospital with primary nephrotic syndrome admitted from September 2016 to April 2018 were analyzed retrospectively in order to observe the relationship between relevant eye damage and clinical medication.@*Results@#There were 37 boys and 12 girls in the 49 cases, of which the average age of onset was (7.6±3.0) years old, and among them there were 22 cases with glucocorticoid high intraocular pressure, 19 cases with glucocorticoid cataract, 8 cases with glucocorticoid high intraocular pressure combined with cataract, but no glaucoma in 49 cases.The shortest time of using glucocorticoid was 15-3 240 days[(863.33±871.46) days]; the cumulative dose of glucocorticoid was (7 865±3 691.66) mg/m2, the left eye pressure was (26.68±5.95) mmHg(1 mmHg=0.133 kPa) and the right eye pressure was (27.71±5.82) mmHg.There was no significant correlation between glucocorticoid using time, cumulative dose and high intraocular pressure(r=-0.158, -0.264, -0.237, -0.361, all P>0.05). All the 19 patients with glucocorticoid cataract and 8 patients with glucocorticoid high intraocular pressure combined with cataract presented posterior capsular opacity, including 23 males and 4 females, and their time of using glucocorticoid was(1 296.67±903.35)days, who were followed up continuously.@*Conclusions@#Glucocorticoid-induced high intraocular pressure and cataract should be paid attention to by clinicians.Once high intraocular pressure or cataract occurs, the dosage of glucocorticoid should be gradually reduced or stopped, at the same time, ophthalmologic treatment should be actively performed to avoid serious eye diseases.
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Objective To explore the clinical characteristics of glucocorticoid induced eye damage in children with primary nephrotic syndrome. Methods The clinical data of steroid－induced high intraocular pressure or cataract in 49 children who were from Zhengzhou Children′s Hospital with primary nephrotic syndrome admitted from September 2016 to April 2018 were analyzed retrospectively in order to observe the relationship between relevant eye damage and clinical medication. Results There were 37 boys and 12 girls in the 49 cases,of which the average age of onset was (7. 6 ± 3. 0)years old,and among them there were 22 cases with glucocorticoid high intraocular pressure,19 cases with glucocorticoid cataract,8 cases with glucocorticoid high intraocular pressure combined with cataract,but no glaucoma in 49 cases. The shortest time of using glucocorticoid was 15 －3 240 days[(863. 33 ± 871. 46)days];the cumulative dose of glucocorticoid was(7 865 ± 3 691. 66)mg/m2 ,the left eye pressure was(26. 68 ± 5. 95)mmHg(1 mmHg﹦0. 133 kPa)and the right eye pressure was(27. 71 ± 5. 82)mmHg. There was no significant correlation between glu﹣cocorticoid using time,cumulative dose and high intraocular pressure( r﹦ －0. 158,－0. 264,－0. 237,－0. 361,all P＞0. 05). All the 19 patients with glucocorticoid cataract and 8 patients with glucocorticoid high intraocular pressure combined with cataract presented posterior capsular opacity,including 23 males and 4 females,and their time of using glucocorticoid was(1 296. 67 ± 903. 35)days,who were followed up continuously. Conclusions Glucocorticoid－in﹣duced high intraocular pressure and cataract should be paid attention to by clinicians. Once high intraocular pressure or cataract occurs,the dosage of glucocorticoid should be gradually reduced or stopped,at the same time,ophthalmologic treatment should be actively performed to avoid serious eye diseases.
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Objective To investigate the differences in clinical manifestations and prognosis between adult and child Henoch-Schonlein purpura(HSP).Methods The data in 320 cases of HSP in Zhengzhou Municipal Children′s Hospital and First Affiliated Hospital of Zhengzhou University from November 2013 to December 2016 were retrospectively analyzed.Then the differences in clinical manifestations and prognosis between adult and child HSP were compared.Results Purpura was mainly distributed in double lower limbs,but the proportion of double upper extremities distribution in adults was higher than that in children(43.8%vs.20.1%).Child HSP was easier to appear the joint symptoms than adult HSP(55.4% vs.26.0%),adult HSP was easier to ap-pear diarrhea(20% vs.1.6%);adult HSP was easier to appear serum IgA level increase and anemia(26.3% vs.3.5%,25% vs. 7.1%).Renal injury in adult HSP was more severe than that in children(78.1% vs.29.0%);the 31-month follow up found that the proportion of adult HSP progressing to chronic renal insufficiency was 9.4%,which in child HSP was 1.3%.Conclusion The great differences in the HSP clinical manifestations exist between adult and child HSP.Adult HSP is easier to appear renal involve-ment and its prognosis is poorer.
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Objective Explore the sodium citrate anticoagulation in the continuity of plasma adsorption closed-circuit circulation of anticoagulation therapy method and effect. Methods Line into the continuity of plasma adsorption treatment of 156 cases of acute drug poisoning patients were randomly(random number) divided into two groups, 78 cases in each group, respectively adopt low molecular heparin (group A), sodium citrate anticoagulation (group B). Contrast analysis of two groups after the therapy began 30 min, 3 h, 6 h before the filter in patients with pressure, transmembrane pressure, pressure drop, at the same time to compare two groups of 10 min before the start of treatment, after treatment began to 3 h, 6 h platelet, coagulation time live enzymes, vein in the body of free Ca2+, Na+and HCO3- 24 h and internal bleeding. Results Two groups in gender, age, clinical diagnosis, blood purification time comparative differences had no statistical significance (P>0.05);Two groups of 30 min after the start of treatment, 3 h, 6 h patients before pressure, transmembrane pressure, filter pressure drop compared differences were no statistical significance (P>0.05); Part of coagulation treatment after low molecular heparin group live enzymes the sodium citrate group significantly prolonged (P<0.01);Platelets, HCO3- the two groups after treatment, intravenous free Ca2+ and Na+ differences had no statistical significance (P>0.05). Conclusions In the continuous plasma adsorption treatment process using sodium citrate anticoagulation with clinical feasibility, safety.
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Objective To explore and provide guidelines for the clinical diagnosis and treatment of primary nephrotic syndrome complicated with acute pancreatitis. Methods The clinical data of 14 children with primary nephrotic syndrome complicated with acute pancreatitis during September 2013 to September 2016 were retrospectively analyzed. Results In 14 children (6 males and 8 females) aged 3 to 15 years. all children presented massive proteinuria, hypoalbuminemia, varying degrees of edema, hyperlipidemia and pain in upper abdomen or left hypochondrium. Seven children had nausea and vomiting, and their amylase in serum and urine fluctuated at 392–802 U/L and 561–3180 U/L, and the lipase level was 339.1±2.52 U/L. After supportive treatment, 13 children were cured from pancreatitis except one who gave up the treatment. Conclusion Due to infection, coagulation disorder, hyperlipidemia and drug application in primary nephrotic syndrome, acute pancreatitis may be induced. Clinician should be alerted to it and early diagnosis and treatment were needed for acute pancreatitis.
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Mycobacterium tuberculosis ( Mtb) is an extremely successful intracellular bacterial pathogen that engages multiple strategies to escape host immune surveillance,so as to survive within host macrophages for long period. Upon the invasion of pathogenic bacteria,the host ubiquitin system plays a critical role in activating the host innate immune responses and associated signaling pathways such as inflammatory and immune responses, autophagy, phagosome maturation and cell death, etc. On the other hand, recent studies have demonstrated that intracellular pathogenic bacteria such as Mtb can secrete a variety of effector proteins into host cells to hijack or co-opt the ubiquitin system to suppress host immune responses. Those pathogen-host interacting interfaces could provide potential novel targets for the development of anti-tuberculosis drugs.
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Objective On patients with mechanical ventilation spontaneous breathing trial (SBT) success, out of breath machine smoothly pulled out after endotracheal intubation for active airway moist sequential therapy of clinical new method and new technology. Methods Between January 2013 and May 2014 respiratory endotracheal intubation implementation of mechanical ventilation with intensive medicine successful withdraw machine pulled out of 135 patients with tracheal intubation, they were divided into group A(68 cases) and group B(67 cases) by random digits table method. The patients in group A were treated with buoy type oxygen device, group B with active airway moist heat treatment unit. The breathing rate, PaO2, SpO2, heart rate, Clinical Pulmonary Infection Score(CPIS) were measured after 72 h of pull out endotracheal intubation in two groups. Sputum viscosity was evaluated by Airway Secretions Score before pull out endotracheal intubation and after 24, 48, 72 h of pull out endotracheal intubation in two groups. Results There were no significant differences between two groups in gender, age, clinical diagnosis, mechanical ventilation time, acute physiology and chronic health evaluation systemⅡrating etc (P>0.05). The breathing rate, heart rate and CPIS score respectively (20.94 ± 0.89), (80.79±4.67) times/min and (7.13 ± 2.54) points after 72 h of pull out endotracheal intubation in group B, and (24.12 ± 0.97), (86.32 ± 5.12) times/min and (8.79±3.56) points in group A, and there were significant differences(t=5.113, 7.298, 5.597, all P0.05). After 24, 48 and 72 h of pull out endotracheal intubation, group B of patients with sputum viscosity was suitable in group A (Z=-2.684,-2.870,-2.771, all P < 0.01). Conclusions Mechanical ventilation in patients with ventilator buoy type oxygen device for the pull out after endotracheal intubation success does not favor the sputum drainage, improve patients with dyspnea and hypoxemia is not obvious. By positive airway plus temperature humidity to sequential therapy is helpful to correct hypoxemia, improve the patients' respiratory function, reduce the breathing difficulties, reduce sputum viscosity, promote the airway drainage unblocked, shortening the time of lung infection.
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@#ObjectiveTo observe the therapeutic effect of moxibustion on heat-sensitive acupoints on Bell's palsy.Methods102 patients with Bell's palsy were divided into observation group (n=52) and control group(n=50). The observation group was treated by moxibustion on the heat-sensitive acupoints plus physical therapy and medication, and the control group was only treated by physical therapy and medication. The therapeutic effect was assessed according to score of facial nerve function before and after the treatment.ResultsThe curative rate of 88.5% in the observation group was better than 62% in the control group. After treatment, the scores significantly improved in two groups (P<0.001), and were significantly better in the observation group than in the control group (P<0.01).ConclusionMoxibustion on the heat-sensitive acupoints has a high therapeutic effect on Bell's palsy.
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Objective To discuss and summarize nursing measures of elderly patients with severe brain injury after tracheotomy. Methods A retrospective analysis was carried out in 60 elderly patients with severe traumatic brain injury after tracheotomy in our hospital from July, 2009 to August, 2010, all patients were given holistic nursing care, including close observation of patients' condition, controlling the suction time, methods and techniques, strict aseptic technique, to effectively prevent infection. Results In the implementation of the patient-centered holistic care, the results were significant, 49 cases survived the acute phase and finally removed tracheal tube. Only 5 patients had pulmonary infection, accounting for 8.3%. 3 patients died due to brain injury and 5 cases were discharged against advice, 3 patients did not gain extubation due to severe brain stem injury. Conclusions The patients with severe head injury need tracheotomy to maintain airway patency, timely call-back, suction, effective airway humidification, prevention of pulmonary infection, reduction of respiratory tract injury is key to successful treatment. The patientcentered holistic care is worthy of wide clinical application.
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Objective To study the reasons and nursing care methods of rehemorrhage in patients with subarachnoid hemorrhage(SAH).Methods The risk factors were compared between the rebleeding in subarachnoid hemonhage patients group and the non-rebleeding group.Results In the rebleeding patients,more patients had the risk factors as being over 60 years-old,hypertension,aneurysm,drinking alcohol,mood swing,defecation and out-of-bed activity,with a significant difference compared with non-rebleeding patients.Conclusions According to the risk factors of subarachnoid hemorrhage,to strengthen the health education to subarachnoid hemorrhage patients is important to the treatment,nursing and rehabilitation of this disease.
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@#Objective To study the influence of center of gravity excursion in standing on function outcome of stroke patients.Methods46 stroke patients were assessed with static posturography in standing,Fugl-Meyer Balance Scale,Barthel Index and the time in hospital.The patients were divided into 2 groups according to posturography results:center of gravity was inclined to the normal side (normal group),center of gravity was inclined to the hemiplegia side (hemiplegia group).ResultsThe ability of balance,walking and activity of daily living(ADL)of the normal group patients were better than that of the hemiplegia group patients,and the in-hospital time was shorter (P<0.001).ConclusionThe center of gravity excursion in standing is highly correlated with functional outcome of stroke patients.
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@#ObjectiveTo study the effect of partial body-weight support and treadmill training in subacute stroke patients.Methods40 stroke patients were randomly arranged into 3 groups: group A (n=14) accepted 8 weeks of routine physical therapy, group B (n=13) accepted additional 6 weeks partial body-weight support and treadmill training at the 3rd week, group C (n=13) accepted additional 3 weeks partial body-weight support and treadmill training at the 6th week. The patients were evaluated with Fugl-Meyer Assessment of Physical Performance(FMA), Barthel Idex(BI) and the Berg Balance Scale(BBS). ResultsThe functional outcome of the initial evaluation with FMA, BI and BBS were no-significantly different, 8 weeks later, that of group B were better than that of group A and group C (P<0.05～0.01), and that of group C were better than that of group A (P<0.05).ConclusionEarly treatment of partial body-weight support and treadmill training can help to improve the lower extremities function.
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@#ObjectiveTo study the correlations between Berg balance scale (BBS) and balance subscale of Fugl-Meyer test (FM-B), and evaluate their practicability for assessing balance function of patients after stroke.Methods68 stroke inpatients were assessed with BBS, FM-B and BPM before training. After training they were re-assessed by the same researcher. The parameters of BPM were sway index, sway tract length and area. The patients were assessed twice with eye opened and eye closed respectively.ResultsThere was no significant difference in the score of FM-B between the first assessment and after training (P>0.05), while that of BBS and BPM after training were better than before the training (P<0.001). There was moderate correlation between FM-B and BBS (r=0.517,P<0.001), but there was no correlation between FM-B and BPM (r=-0.074～-0.247,P>0.05). There was moderate negative correlation between BMP and BBS (r=-0.410～-0.587,P<0.01).ConclusionBBS and BPM are good tools for assessing balance function of stroke patients; FM-B shows low sensitivity and is not suitable for assessing stroke patients.
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@#Objective To study the balance function of normal persons and to explore the differences in gender and age groups.Methods Forty parameters of 445 normal persons(16-70 years old, 205 of male, 240 of female ) were detected by static posturography while they were in seat, double foot standing with opening and closing eyes, and single foot standing with opening eyes. The results of male and female, standing with opening eyes and closing eyes, left foot standing and right foot standing were compared.Results Everyone's center of gravity was distributed in A zone while they were in seat. At standing with opening eyes and closing eyes, the center of gravity in A zone were in 429 subjects( 96.4%) and 436 subjects( 98.0%). Most parameters showed significant difference between the women and the men, opening eyes and closing eyes, left foot standing and right foot standing, different age groups. The stability in closing eyes was better than that in opening eyes, right foot standing was better than left foot standing. Most values of 20—39 years old group were the best, 70—79 years old group were the worst.Conclusion Static posturography can evaluate human balance function objectively and quantitatively. The stability is related to age and gender. To judge the balance function, the subject's age and sex must be taken into account.